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KMID : 0616120090400020123
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Korean Journal of Pharmacognosy
2009 Volume.40 No. 2 p.123 ~ p.127
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Biological Activity of Flavonoids Isolated from Aster tataricus L.
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Choi Doo-Youn
Choi Eun-Jin
Jin Qing-Long
Shin Ji-Eun
Woo Eun-Rhan
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Abstract
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In an ongoing investigation into anti-oxidative compounds from natural products, the EtOAc soluble fraction of Aster tataricus L. (Compositae) showed significant anti-oxidative activity on the NBT superoxide scavenging assay. By means of an activity-guided purification, three flavonoids, kaempferol (1), quercetin (2), astragalin (3) and one monoterpene glycoside, shionoside A (4) were isolated. Their structures were determined spectral analyses. Compounds 2 and 3 showed potent antioxidative activity, while, compounds 1 and 4 were inactive >120. In addition, these compounds were examined for the effect of interleukin-6 (IL-6) production in TNF- stimulated MG-63 cell. Compounds 1-3 showed negligible inhibitory activity against IL-6 production in stimulated cell, and compound 4 was inactive.
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KEYWORD
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Aster tataricus L., antioxidant, IL-6 inhibitory activity
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